Proliferative nephritis in childhood-onset systemic lupus erythematosus: current therapeutic approaches and future

Renal involvement occurs in 50-75% of children with childhood-onset systemic lupus erythematosus (cSLE). Proliferative lupus nephritis (LN) represents the most common pattern of renal involvement in cSLE. Despite aggressive treatment, progression to end stage renal disease can occur in up to 5-10% of children. Over the last 2 decades, tremendous advancements have been made in the treatment of pediatric LN. Special considerations in children need to address the impact of disease and therapy on both physical and psychological growth and development. This review will focus on pivotal clinical trials in the treatment of proliferative LN, with a focus on pediatric data when available. This article is included in the Lupus nephritis and channel. neuropsychiatric lupus Dawn M. Wahezi ( ) Corresponding author: [email protected] Wahezi DM. How to cite this article: Proliferative nephritis in childhood-onset systemic lupus erythematosus: current therapeutic 2015, :128 (doi: approaches and future perspectives [version 1; referees: 1 approved, 1 approved with reservations] F1000Research 4 ) 10.12688/f1000research.6533.1 © 2015 Wahezi DM. This is an open access article distributed under the terms of the , which Copyright: Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the (CC0 1.0 Public domain dedication). Creative Commons Zero "No rights reserved" data waiver The author(s) declared that no grants were involved in supporting this work. Grant information: Competing interests: No competing interests were disclosed. 27 May 2015, :128 (doi: ) First published: 4 10.12688/f1000research.6533.1 Referee Status: